Table 1.
Subject Characteristics stratified by KL grade.
| WOMAC | ||||||||
|---|---|---|---|---|---|---|---|---|
| Age (yrs) |
Height (cm) |
Weight (kg) |
BMI | KL grade |
Pain | Stiffness | Function | |
|
Controls (n=19) |
||||||||
| Mean | 39.10 | 172.5 | 70.79 | 23.47 | 0.00 | 3.26 | 1.63 | 6.79 |
| SD | 10.15 | 9.09 | 12.66 | 3.44 | 0.00 | 3.26 | 1.67 | 8.98 |
|
Mild OA (n=26) |
||||||||
| Mean | 52.27 * | 170.04 | 75.28 | 26.00 | 1.46 * | 3.19 | 1.88 | 10.42 |
| SD | 10.30 | 9.06 | 13.49 | 4.01 | 0.51 | 3.14 | 1.24 | 11.11 |
| p-value (vs. controls) |
<0.001 | 0.200 | 0.998 | 0.842 | 0.551 | |||
|
Severe OA (n=18) |
||||||||
| Mean | 62.61* # |
166.58 | 80.89 | 29.33* # |
3.47 *# |
10.72* # |
4.67 *# | 35.55 *# |
| SD | 10.33 | 8.48 | 16.67 | 6.78 | 0.52 | 4.48 | 1.64 | 14.15 |
| p-value (vs. controls) |
<0.001 | 0.001 | <0.001 | <0.001 | <0.001 | |||
| p-value (vs. mild OA) |
0.005 | 0.071 | <0.001 | <0.001 | <0.001 | |||
| ANOVA Prob >F |
<0.001 | 0.137 | 0.106 | 0.002 | <0.001 | <0.001 | <0.001 | |
|
Patients (mild and severe) |
||||||||
| Mean | 56.50 * | 168.62 | 77.57 | 27.36 * | 6.27 * | 3.03 * | 20.70 * | |
| SD | 11.42 | 8.89 | 14.95 | 5.50 | 5.26 | 1.97 | 17.53 | |
| p-value (vs. controls) |
<0.001 | 0.120 | 0.089 | 0.006 | 0.025 | 0.009 | 0.002 | |
*
Significantly different than control (p<0.05).
#
Significantly different than mild OA (p<0.05)
BMI=body mass index; KL= Kellgren-Lawrence; WOMAC=Western Ontario and McMasters Universities Arthritis Index; SD= standard deviation. Controls are defined as subjects having a KL score of 0, Mild OA are defined as subjects with a KL score of 1 or 2, and Severe OA are defined as subjects having a KL score of 3 or 4.