Table I.
Group | Treatment |
n | Survival (days) | ||
---|---|---|---|---|---|
Procedure | Dose | Duration | |||
1 | MVTX | None | — | 5 | 10, 10, 10, 10, 13 |
2 | MVTX | 0.32 mg/kg | 14 Days | 6 | (114), >155, >157, >164, >226, >227 |
3 | MVTX | 0.64 mg/kg | 14 Days | 7 | (12*), 18,** (114), (133), (134), >161, >194, |
4 | MVTX | 0.64 mg/kg | 14 Days, then weekly | 3 | (203), >218, >224 |
5 | SBTX | None | — | 7 | 9, 10, 11, 12, 13, 13, 14 |
6 | SBTX | 0.32 mg/kg | 14 Days | 6 | (57*), (88*), (102*), >169, >213, >217 |
7 | SBTX | 0.64 mg/kg | 14 Days | 10 | 42,* 105,* (107), 112,* >120, >121, >121, >122, 163,* >163,* >263 |
8 | SBTX | 0.64 mg/kg | 14 Days, then weekly | 4 | (109), >212, >212, >242 |
Ileus;
chylothorax.
Note: The animals with survival limes in parentheses were killed for histologic studies. These rats were in good condition at the time of death, except when indicated by * or ** within the parentheses. The other rats with survival times marked * or ** died in the cage or were killed because they were dying and could not be used for the special pathologic studies.