Table II.

Summary of findings in the small bowel of rats killed 57 to 203 days after surgery for detailed histopathologic studies

		Villi
Dose of FK 506	Time sample in days	Necrosis	Blunting	Cryptitis	Depleted lamina propria	Arteriopathy	Thickened muscularis	Peyer’s patches	Mesenteric lymph nodes
0.32 mg/kg/day × 14 days
MVTX (n = 1) (group 2)	114	No	Focal	Focal	No	No	No	Normal	Depleted and scarred
SBTX (n = 3) (group 6)	57,* 88,* 102*	Focal	Diffuse	Diffuse	Depleted	Yes	Yes	Absent	Depleted and scarred
0.64 mg/kg/day × 14 days
MVTX (n = 3) (group 3)	114, 133, 134	No	Focal (Fig. 4)	Rare	No	No	No	Normal (Fig. 4)	Normal (2 of 3)** (Fig. 4)
SBTX (n = 1) (group 7)	107	No	Diffuse (Fig. 5)	Common (Fig. 5)	Depleted (Fig. 5)	No	Yes (Fig. 5)	Absent (Fig. 5)	Depleted and scarred (Fig. 6)
0.64 mg/kg/day × 14 days and weekly
MVTX (n = 1) (group 4)	203	No	None (Fig. 3)	None	No	No	No	Normal (Fig. 3)	Normal
SBTX (n = 1) (group 8)	109	No	Focal	None	No	No	No	Normal	Intact but distorted

^*Moribund at time of sacrifice (see Table 1);

^**Other node depleted and scarred.

Depleted, Lymphoid depletion.