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. 2010 Jul 12;588(Pt 17):3255–3266. doi: 10.1113/jphysiol.2010.194779

Figure 3. Single channel conductance is unaffected by the presence of caveolin.

Figure 3

A and B, single-channel Kir6.1/SUR2B currents recorded at membrane potentials of 80 mV and −80 mV from cell-attached patches from caveolin-null HEK293 cells (A) or HEK293 cells stably expressing caveolin-1 (B). Currents were recorded in 140 mm extracellular K+ and 10 μm pinacidil. All-point amplitude histograms shown on the right of each trace. C, mean single channel amplitudes for Kir6.1/SUR2B channels expressed in caveolin-null HEK293 cells (filled symbols) or HEK293-caveolin-1 cells (open symbols) plotted against voltage (means ±s.e.m.). D, open probability of pinacidil-evoked Kir6.1/SUR2B channels recorded in caveolin-null HEK293 or HEK293 caveolin-1 cells at −40 mV (*P < 0.05).