Table 2.

HRs (95% CIs) for the association of long-term mortality to baseline MR, LVEF and BNP

	Univariate	p Value	Multivariate model 1 including MR, LVEF and BNP (or MR/LVEF* and BNP)	p Value	Multivariate model 2 including MR or LVEF or BNP or MR/LVEF* + confounders†	p Value	Multivariate model 3 including MR, LVEF and BNP (or MR/LVEF* and BNP) + confounders†	p Value
All-cause mortality
MR >1.0	3.25 (2.41 to 4.37)	<0.0001	2.28 (1.67 to 3.12)	<0.0001	1.82 (1.29 to 2.59)	0.0007	1.53 (1.06 to 2.19)	0.02
LVEF <0.40	3.48 (2.63 to 4.61)	<0.0001	2.38 (1.76 to 3.23)	<0.0001	2.34 (1.70 to 3.22)	<0.0001	1.94 (1.38 to 2.73)	0.0001
BNP >373 pmol/l	2.86 (2.20 to 3.72)	<0.0001	1.96 (1.47 to 2.61)	<0.0001	1.79 (1.33 to 2.40)	0.0001	1.45 (1.06 to 1.99)	0.02
MR/LVEF score*	2.81 (2.33 to 3.38)	<0.0001	2.33 (1.90 to 2.85)	<0.0001	1.88 (1.51 to 2.34)	<0.0001	1.73 (1.38 to 2.17)	<0.0001
Readmission to hospital for CHF
MR >1.0	3.84 (2.52 to 5.86)	<0.0001	2.58 (1.66 to 4.01)	<0.0001	2.49 (1.56 to 3.96)	0.0001	2.08 (1.29 to 3.35)	0.003
LVEF <0.40	5.14 (3.49 to 7.57)	<0.0001	3.54 (2.33 to 5.38)	<0.0001	4.14 (2.65 to 6.47)	<0.0001	3.41 (2.14 to 5.42)	<0.0001
BNP >373 pmol/l	3.30 (2.27 to 4.80)	<0.0001	2.01 (1.34 to 3.03)	0.0008	2.12 (1.38 to 3.24)	0.0005	1.51 (0.96 to 2.38)	0.07
MR/LVEF score*	3.66 (2.82 to 4.74)	<0.0001	3.03 (2.29 to 4.02)	<0.0001	2.91 (2.15 to 3.94)	<0.0001	2.66 (1.94 to 3.65)	<0.0001

^*Per step in 0–1–2 score, where MR grade >1 and LVEF <0.40 were assigned one score point each.

^†Adjusted for age, gender, smoking, diabetes, hypertension, hypercholesterolaemia and history of diabetes, MI, angina, CHF, PCI/CABG, GFR <60 ml/min and current diagnosis of ACS type.

ACS, acute coronary syndromes; BNP, brain natriuretic peptide; CABG, coronary artery bypass grafting; CHF, congestive heart failure; GFR, glomerular filtration rate; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MR, mitral regurgitation, PCI, percutaneous coronary intervention.