TABLE 1.

Cytotoxicity (CC₅₀) and activity (IC₅₀) against four dermatophyte and four Candida species

Human cell or fungal isolate	Activitya ± SD
	TRB	MC	ITC	PRC
Cells
MRC-5	63.00 ± 1.73	29.67 ± 13.32	49.33 ± 14.50	53.33 ± 18.48
Fungal isolates
Microsporum canis B68128	0.10 ± 0.05	0.23 ± 0.16	2.02 ± 2.45	0.18 ± 0.06
Trichophyton mentagrophytes B70554	0.06 ± 0.04	0.40 ± 0.28	0.37 ± 0.39	0.15 ± 0.16
T. rubrum B68183	0.07 ± 0.05	0.33 ± 0.26	0.56 ± 0.48	0.35 ± 0.14
T. rubrum J941704	0.03 ± 0.02	0.14 ± 0.09	0.98 ± 1.31	0.19 ± 0.19
T. quinckeanum B68683	0.01 ± 0.01	0.79 ± 0.49	2.93 ± 2.91	1.34 ± 1.21
Candida albicans B59163	3.57 ± 1.39	0.30 ± 0.22	1.41 ± 1.20	0.04 ± 0.03
C. albicans B2630	64.00 ± 0.00	2.50 ± 2.08	1.39 ± 1.86	1.83 ± 2.34
C. glabrata B63155	30.66 ± 23.68	0.12 ± 0.06	3.74 ± 4.63	0.65 ± 0.15
C. kefyr B46120	6.33 ± 4.80	0.03 ± 0.03	0.40 ± 0.35	0.13 ± 0.06
C. krusei B68404	64.00 ± 0.00	1.40 ± 0.57	4.21 ± 4.90	0.87 ± 0.50

^aFor MRC-5 cells, the CC₅₀ (the concentration at which 50% of the MRC-5 cells are killed) is given. For fungal isolates, the IC₅₀ (the concentration in μM at which growth is inhibited for 50% compared to untreated controls) is given. Averages of five independent repeats are expressed, together with the standard deviation (SD). Conversion factors to be used for the IC₅₀s in μg/ml: TRB, × 0.33; MC, × 0.42; ITC, × 0.70; PRC, × 0.66.