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Pharmacokinetics (PK) after oral administration of pramiconazole, itraconazole, and terbinafine to guinea pigs
| PK parameter | Result with: |
||
|---|---|---|---|
| PRCb | ITCc | TRBd | |
| Cmax (μg/ml)a | 0.18 | 0.35 | 0.06 |
| Tmax (min) | 240 | 120 | 42 |
| t1/2 (h) | 23 | 13.9 | 6.6 |
Plasma concentrations were normalized to a dose of 10 mg/kg.
40 mg/kg; source, Janssen Pharmaceutica, unpublished data.
20 mg/kg; source, Sobue et al. (22).
10 mg/kg; source, Janssen Pharmaceutica, unpublished data.
