TABLE 5.

Susceptibility of the subtype A BTV selected by MK-4965, EFV, and ETV to the NNRTIs^a

Selection compound	Selected mutation(s)	Fold change in EC50 against:
		MK-4965	EFV	ETV
MK-4965	A200E/F227C	31 ± 4.2	15 ± 4.4	7.1 ± 1.7
EFV	V106M	0.55 ± 0.25	16 ± 6.7	0.74 ± 0.31
	V106(V/M)/F227(F/C)	36 ± 8.9	113 ± 18	2.6 ± 1.5
ETV	Y181C	7.7 ± 1.6	2.3 ± 0.3	32 ± 10
	Y181C/A200E	9.3 ± 2.0	1.9 ± 0.46	27 ± 6

^aExperiments were performed at least in quadruplicate.