TABLE 4.
In vitro activities of ACHN-490 and comparators against AG-R isolatesa
| Species (n) | AG | MIC50 (μg/ml) | MIC90 (μg/ml) | MIC range |
|---|---|---|---|---|
| Citrobacter spp. (9) | ACHN-490 | 0.5 | —b | 0.25-1 |
| AMK | 32 | — | 2-64 | |
| GEN | >64 | — | 2 to >64 | |
| BPR | 1 | — | <0.03 to >32 | |
| CIP | 8 | — | <0.015 to >16 | |
| IMI | 0.5 | — | 0.125-4 | |
| TGC | 0.5 | — | 0.25-1 | |
| Escherichia coli (24) | ACHN-490 | 1 | 2 | 0.5-16 |
| AMK | 16 | 32 | 2-64 | |
| GEN | 64 | >64 | 1 to >64 | |
| BPR | >32 | >32 | <0.03 to >32 | |
| CIP | >16 | >16 | <0.015 to >16 | |
| IMI | 0.125 | 0.25 | 0.06-0.5 | |
| TGC | 0.25 | 0.5 | 0.06-1 | |
| Enterobacter spp. (20) | ACHN-490 | 0.5 | 1 | 0.25-8 |
| AMK | 8 | 64 | 1 to >64 | |
| GEN | 32 | >64 | 0.5 to >64 | |
| BPR | >32 | >32 | 0.06 to >32 | |
| CIP | 1 | >16 | <0.015 to >16 | |
| IMI | 1 | 4 | 0.125 to >16 | |
| TGC | 0.5 | 4 | 0.125-8 | |
| Klebsiella spp. (45) | ACHN-490 | 0.5 | 1 | 0.25-8 |
| AMK | 32 | >64 | 2 to >64 | |
| GEN | 32 | >64 | 0.5 to >64 | |
| BPR | >32 | >32 | 0.125 to >32 | |
| CIP | 16 | >16 | <0.015 to >16 | |
| IMI | 0.25 | >16 | 0.06 to >16 | |
| TGC | 1 | 2 | 0.125-8 | |
| Proteus mirabilis (16) | ACHN-490 | 4 | 8 | 1-16 |
| AMK | 8 | 64 | 8 to >64 | |
| GEN | 32 | >64 | 1 to >64 | |
| BPR | 0.125 | >32 | <0.03 to >32 | |
| CIP | 2 | >16 | 0.03 to >16 | |
| IMI | 4 | 8 | 0.25 to >16 | |
| TGC | 4 | 8 | 1-8 | |
| Proteae, indole+ (8) | ACHN-490 | 8 | — | 4-16 |
| AMK | 8 | — | 4-32 | |
| GEN | >64 | — | 16 to >64 | |
| BPR | >32 | — | 0.06 to >32 | |
| CIP | 16 | — | 1 to >16 | |
| IMI | 1 | — | 1-2 | |
| TGC | 2 | — | 2-8 | |
| Serratia spp. (9) | ACHN-490 | 1 | — | 0.5-4 |
| AMK | 8 | — | 0.5 to >64 | |
| GEN | 64 | — | 1 to >64 | |
| BPR | >32 | — | 0.5 to >32 | |
| CIP | 4 | — | 0.06-16 | |
| IMI | 1 | — | 0.125-2 | |
| TGC | 2 | — | 1-8 | |
| Staphylococcus spp. (49) | ACHN-490 | 1 | 2 | 0.25-4 |
| AMK | 16 | >64 | 0.5 to >64 | |
| GEN | 32 | >64 | 0.25 to >64 | |
| BPR | NDc | ND | ND | |
| CIP | 16 | >16 | 0.125 to >16 | |
| IMI | ND | ND | ND | |
| TGC | 0.25 | 0.5 | 0.03-0.5 | |
| Acinetobacter spp. (67) | ACHN-490 | 16 | 32 | 1 to >64 |
| AMK | >64 | >64 | 4 to >64 | |
| GEN | >64 | >64 | 2 to >64 | |
| BPR | >32 | >32 | 0.5 to >32 | |
| CIP | >16 | >16 | 0.25 to >16 | |
| IMI | 2 | >16 | 0.125 to >16 | |
| TGC | 2 | 16 | 0.5 to >16 | |
| Pseudomonas aeruginosa (51) | ACHN-490 | 8 | 64 | 0.5 to >64 |
| AMK | 16 | >64 | 1 to >64 | |
| GEN | >64 | >64 | 8 to >64 | |
| BPR | 16 | >32 | 4 to >32 | |
| CIP | 8 | >16 | 0.03 to >16 | |
| IMI | 4 | 16 | 0.125 to >16 | |
| TGC | 16 | >16 | 1 to >16 |
a
ACHN-490 retains activity in the presence of AGRMs that inactivate AMK and GEN and in strains that are resistant to several other antibiotic classes.
b
The MIC90 was not calculated for groups for which n was <10.
c
ND, not determined.