TABLE 5.
Activities of ACHN-490 against AG-R clinical isolates with a single AMEa
| Species | Phenotype | n | Geometric mean MIC (μg/ml) of: |
||
|---|---|---|---|---|---|
| AMK | GEN | ACHN-490 | |||
| Enterobacteriaceae | |||||
| E. coli | ATCC 25922 (normal) | 1 | 3 | 1 | 1 |
| K. pneumoniae | AAC(3)-I | 1 | 4 | 32 | 1 |
| Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, E. coli, Klebsiella oxytoca, K. pneumoniae, Serratia liquefaciens | AAC(3)-II | 22 | 4 | 62 | 1 |
| E. coli, K. pneumoniae | AAC(3)-IV | 2 | 2 | 16 | 1 |
| C. freundii, E. aerogenes, E. cloacae, E. coli, K. oxytoca, K. pneumoniae, S. marcescens | AAC(6′)-I | 26 | 30 | 1 | 1 |
| Enterobacter gergoviae, K. pneumoniae, E. cloacae, E. coli, S. marcescens | ANT(2″)-I | 7 | 2 | 35 | 1 |
| Staphylococci | |||||
| S. aureus | ATCC 29213 (normal) | 1 | 3 | 1 | 1 |
| S. aureus, S. epidermidis | ANT(4′,4″)-I | 9 | 13 | 1 | 1 |
| S. aureus, S. epidermidis | APH(2″) + AAC(6′)-I | 22 | 18 | 50 | 1 |
| S. aureus, S. epidermidis | APH(3′)-III | 14 | 4 | 1 | 1 |
| A. baumannii | (Normal) | 1 | 4 | 1 | 2 |
| AAC(3′)-I | 2 | 4 | 16 | 4 | |
| ANT(2″)-I | 1 | 16 | >64 | 2 | |
| APH(3′)-VI | 3 | >64 | 4 | 3 | |
| P. aeruginosa | ATCC 27853 (normal) | 1 | 2 | 1 | 3 |
| AAC(6′)-II | 5 | 14 | 64 | 6 | |
| ANT(2″)-I | 5 | 8 | 56 | 3 | |
a
ACHN-490 activity was not altered by the presence of various AMEs. Only isolates with a single AME are reported here; those with combinations of AMEs (other than APH(3′)-I/II, which generates kanamycin/neomycin resistance) were excluded for the sake of clarity.