TABLE 1.

Final estimates of the best-fit model parameters^a

Parameter	Point estimate	95% confidence limit
		Upper	Lower
Kg (h−1)	1.3078	1.17	1.47
Nmax (108 CFU/ml)	8.3357	6.886	10.715
Kk (h−1)	2.79	2.5	3.05
C50k (mg/liter)	0.51	0.22	0.68
C50b (mg/liter)	40.31	—
H	0.5	0.3	0.62
C50a (mg/liter)	962.19	367.2	2615
Ha	0.592	0.542	0.662
Log N50 (CFU/ml)	6.55	—
Q	0.8	—

^aK_g, growth rate constant for bacterial population; N_max, maximum population size; K_k, maximal kill rate constant for bacterial population; C_50k, concentration to achieve 50% maximal kill rate of the initial population; C_50b, concentration to achieve 50% maximal kill rate of the most resistant population; H, sigmoidicity constant for bacterial population; C_50a, concentration to achieve 50% maximal adaptation rate; Ha, sigmoidicity constant for bacterial adaptation; N₅₀, bacterial population in which 50% drug concentration is in effect; Q, sigmoidicity constant for effective drug concentration; —, unable to determine. The nonlinear confidence region plotting method was found to be inadequate. The sum of squares flattened off in the case of these parameters.