TABLE 3.
Parameter estimates for the pharmacodynamic model of the effects of artemether and dihydroartemisinin in pediatric patients with uncomplicated malaria
| Parameter | Estimate (95% CI)a | IIV, % CV (95% CI)a | Parameter description |
|---|---|---|---|
| Pinit (parasites/μl) | 1 (fixed) | 119.2 (98-161) | Initial parasitemia |
| VPT (h) | 15.5 (9.7-21.5) | NEb | Mean visible parasite transit time |
| MTT (h) | 48.5 (48.0-49.1) | NE | Mean parasite transit time |
| Patients | |||
| REPLp | 4 (3.6-4.4) | NE | Replication factor |
| Ap | 0 (fixed) | NE | Amplitude of oscillations |
| kspleen | 0.26 (fixed)c | NE | Rate of elimination of dead or injured parasites |
| Asymptomatic children | |||
| REPLa | 1 (fixed) | NE | Replication factor |
| Aa | 1.01 (0.71-1.37) | NE | Amplitude of oscillations |
| Drug effects | |||
| SARM/DHA | 0.073 (0.049-0.423) | NE | Slope of the ARM and DHA effect |
| σ (%) | 138 (125-258) | Residual error |
a
95% CI from 1,000 nonparametric bootstrap data sets.
b
NE, not estimated.
c
The estimate was fixed to a literature value from Gordi et al. (9).