TABLE 1.
Patient characteristicsa
| Characteristic | Value |
|---|---|
| No. of patients | 92 |
| Age (yr) | 57.2 ± 14.3 |
| Gender (no. M/no. F) | 67/25 |
| Body wt (kg) | 75.2 ± 18.2 |
| CLCR (ml/min)b | 84.8 (6.1-349.5) |
| Normalized dose of linezolid (mg/kg/12 h) | 8.37 ± 1.74 |
| Hospital admission (no. [%] of patients) | |
| Surgical ward | 40 (43.5) |
| ICU | 28 (30.4) |
| Medical ward | 24 (26.1) |
| Main reason for linezolid treatment (no. [%] of patients) | |
| Bloodstream infections | 18 (19.6) |
| CNS infections | 18 (19.6) |
| Empirical use for severe sepsis | 16 (17.4) |
| Intra-abdominal infections | 11 (12.0) |
| Hospital-acquired pneumonia | 10 (10.9) |
| Bone/joint infections | 10 (10.9) |
| Cardiosurgical infections/endocarditis | 8 (8.7) |
| SST infections | 1 (0.9) |
a
Values are expressed as means ± standard deviations, median (range), or numbers (percentages). Abbreviations: CLCR, estimated creatinine clearance by means of the Cockcroft and Gault formula; CNS, central nervous system; ICU, intensive care unit; SST, skin and soft tissue; TDM, therapeutic drug monitoring; M, male; F, female.
b
At time of first TDM.