TABLE 2.
Comparison of linezolid dosages, administration routes, and most frequent drug cotreatments in cases with trough levels (Cmin) of ≥10 mg/liter versus those with trough levels of <10 mg/liter
| Parameter | No. (%) of cases by linezolid Cmin: |
P value | |
|---|---|---|---|
| ≥10 mg/liter (n = 33) | <10 mg/liter (n = 247) | ||
| Linezolid administration route | |||
| Intravenous | 21 (63.6) | 157 (63.6) | 0.847 |
| Oral | 12 (36.4) | 90 (36.4) | 0.845 |
| Linezolid dosage, median (IQ range) (mg/kg/q12h) | |||
| Overall | 9.3 (7.5-10.2) | 8.0 (7.1-10.0) | 0.067 |
| Intravenous | 10.0 (7.9-10.0) | 8.0 (7.1-10.0) | 0.071 |
| Oral | 7.9 (7.9-10.3) | 8.5 (7.1-10.0) | 0.876 |
| Cotreatments | |||
| Omeprazole | 26 (78.8) | 68 (27.5) | <0.001 |
| Amiodarone | 7 (21.2) | 6 (2.4) | <0.001 |
| Amlodipine | 7 (21.1) | 13 (5.2) | 0.003 |