TABLE 4.
Characterization of XDR-TB isolates through identification of mutations in drug target genes
| Strain | Mutation(s) in drug target gene |
|||
|---|---|---|---|---|
| rpoB (rifampin) | katG (isoniazid) | gyrA (FQ) | rrs (kanamycin, capreomycin, amikacin) | |
| 625 | S531L, G566R, I569L | S315T, R463L | A90V, S95T | A1401G |
| 761 | S531L, Q510P | S315T, R463L | D94N, S95T | G1484T |
| 2301 | S531L | R463L, E217G | D94G, S95T | A1401G |
| 2403 | Q510P, L511V, S531L | S315T, R463L | A90V, S95T | A1401G |
| 2474 | H526Y | D329A, R463L | D94G, S95T | A1401G |
| 2911 | D516V | S315T, R463L | D94G, S95T, R128S, Y129C | A1401G |
| H37Rv | No mutation | No mutation | No mutation | No mutation |