TABLE 5.
XDR-TB isolates with point mutations in the rpoB gene
| XDR strain | Rifampin MIC (μg/ml) | Mutation | Nucleotide change | Amino acid change | Mutation type |
|---|---|---|---|---|---|
| 625 | >16 | S531L | C→T | Ser→Leu | Previously reported |
| 761 | >16 | Q510P | A→C | Gln→Pro | This study |
| S531L | C→T | Ser→Leu | Previously reported | ||
| 2301 | >16 | S531L | C→T | Ser→Leu | Previously reported |
| 2403 | Q510P | A→C | Gln→Pro | This study | |
| L511H | T→A | Leu→His | Previously reported | ||
| S531L | C→T | Ser→Leu | Previously reported | ||
| 2474 | >16 | H526Y | C→T | His→Tyr | Previously reported |
| 2911 | 16 | D516V | A→T | Asp→Val | This study |