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Activity of BI 201335, telaprevir, and boceprevir against representative serine and cysteine proteases
| Inhibitor | IC50 (nM) against the following proteasea: |
|
|---|---|---|
| HLE | CatB | |
| BI 201335 | >30,000 | 26,000 ± 1,900 |
| Telaprevir | 680 ± 10 | 2,300 ± 900 |
| Boceprevir | 17,000 ± 1,000 | 6,200 ± 1,000 |
Fifty percent concentrations (IC50s) shown are means ± standard deviations from three separate experiments. HLE, human leukocyte elastase; CatB, cathepsin B.
