TABLE 6.
Oral pharmacokinetic parameters for BI 201335
| Pharmacokinetic parametera | Valueb for pharmacokinetic parameter in the following animal: |
||
|---|---|---|---|
| Rat | Monkey | Dog | |
| Cmax (μM) | 0.41 | 2.0 ± 0.3 | 3.8 ± 0.3 |
| Tmax (h) | 1.5 | 2.0 ± 0.0 | 0.83 ± 0.17 |
| AUC (μM·h) | 1.55 | 8.3 ± 0.9 | 13 ± 3 |
| AUC0-∞ (μM·h) | 1.63 | 8.3 ± 0.9 | 14 ± 3 |
| MRT p.o. (h) | 3.18 | 3.7 ± 0.1 | 2.6 ± 0.3 |
a
Abbreviations: Cmax, maximum concentration of drug in serum; Tmax, maximum concentration of drug in serum; AUC, area under the concentration-time curve; AUC0-∞, area under the concentration-time curve from 0 h to infinity; MRT, mean retention time; p.o., per os (oral).
b
Values are arithmetic means ± standard errors for three males, except for rats, for which samples from three animals were pooled for analysis.