. 2010 Aug 23;54(11):4556–4560. doi: 10.1128/AAC.01762-09

TABLE 2.

MICs of β-lactams for the recombinant clones, the recipient strain E. coli TOP10, and the OmpC/OmpF porin-deficient strain E. coli HB4

E. colistrain	β-Lactam MIC (μg/ml)
E. colistrain	Cefoxitin	Cefuroxime	Cefotaxime	Ceftazidime	Cefepime	Imipenem	Ertapenem	Meropenem
TOP10(pCMY-2)^a	128	128	128	256	1	0.5	0.064	0.064
TOP10(pACT-1)^a	512	512	64	128	0.25	0.25	0.016	0.032
TOP10(pDHA-1)^a	32	128	8	64	0.064	0.25	0.012	0.032
TOP10(pFOX-1)^a	512	256	16	64	0.5	0.25	0.032	0.125
TOP10(pACC-1)^a	2	1	1	8	0.125	0.125	0.006	0.032
TOP10(pAmpC-B2)^a	128	128	0.5	1	0.06	0.125	0.064	0.032
TOP10	2	1	0.06	0.06	0.06	0.125	0.006	0.032
HB4(pCMY-2)^a	>512	>512	256	>512	16	32	256	8
HB4(pACT-1)^a	>512	>512	64	>512	4	16	256	4
HB4(pDHA-1)^a	>512	>512	128	256	2	2	16	1
HB4(pFOX-1)^a	>512	>512	32	512	8	0.5	4	0.75
HB4(pACC-1)^a	256	128	4	16	4	0.5	2	0.5
HB4(pAmpC-B2)	512	512	4	8	1	0.5	2	0.032
HB4	256	32	4	4	1	0.25	1	0.032

E. coli TOP10(pCMY-2), E. coli TOP10(pACT-1), E. coli TOP10(pDHA-1), E. coli TOP10(pFOX-1), E. coli TOP10(pACC-1), and E. coli TOP10(pAmpC-B2) produced CMY-2, ACT-1, DHA-1, FOX-1, ACC-1, and the chromosome-borne cephalosporinase of E. coli EC6. E. coli HB4(pCMY-2), E. coli HB4(pACT-1), E. coli HB4(pDHA-1), E. coli HB4(pFOX-1), E. coli HB4(pACC-1), and E. coli HB4(pAmpC-B2) produced CMY-2, ACT-1, DHA-1, FOX-1, ACC-1, and the chromosome-borne cephalosporinase of E. coli EC6.