Stereomicroscope images of white (a), yellow (b), and off-white (c) granules and light microscope images of white (d), yellow (e), and off-white (f) granules from the Synthetic-1 reactor. The images of white and yellow granules were taken on day 63 of Synthetic-1 operation, and the images of off-white granules were taken on day 133 of Synthetic-1 operation. White and yellow granules were present in the reactor only during the initial stages of granulation, after which a single homogeneous off-white granule population developed. All scale bars, 500 μm.