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Production of penicillin V and the intracellular accumulation of β-lactam intermediates in P. chrysogenum strains that vary in the number of biosynthetic gene clusters after 5 days of fermentation. (A) Extracellular penicillin V production (open squares) and phenoxyacetic acid (POA) levels (closed squares). (B) Intracellular levels of ACV (closed triangles), IPN (open diamonds), and penicillin V (closed diamonds). gDW, gram (dry weight) of cells.
