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. 2010 Dec 1;137(23):4061–4072. doi: 10.1242/dev.052118

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Fig. 8. — Spatial and temporal requirement of Jag1 during IHBD development. BEC specification and initial ductal plate formation occurs in a mesenchymal Jag1-independent manner (steps 1 and 2). Jag1 expression in the PVM controls the complete formation of the second layer of the ductal plate, allowing the BECs to eventually remodel into a lumenized duct. Expansion of PVM also appears to be dependent on Jag1 signaling (steps 3 and 4). Loss of Jag1 expression in the PVM causes duct development to stall midway during ductal plate morphogenesis (step 3), leading to a paucity of bile ducts.