Table 2.
Genes with differential expression in hypoxia, following ketoconazole treatment, and in a upc2Δ background
| Locus tag | Gene | Description | Log fold change |
||
|---|---|---|---|---|---|
| Hypoxia | Ketoconazole treatment | upc2Δ background | |||
| Ergosterol synthesis pathway | |||||
| orf19.767 | ERG3 | C-5 sterol desaturase | 2.47 | 1.59 | −2.34 |
| orf19.922 | ERG11 | Lanosterol 14-alpha-demethylase | 1.49 | 1.14 | −1.89 |
| CFEM family | |||||
| orf19.5636 | RBT5 | GPI-anchored cell wall protein involved in hemoglobin utilization | 2.77 | 1.40 | −2.17 |
| orf19.5635 | PGA7 | Hyphal surface antigen | 1.90 | 1.16 | −1.48 |
| Iron metabolism | |||||
| orf19.5634 | FRP1 | Predicted ferric reductase | 3.39 | 2.53 | −1.97 |
| orf19.4215 | FET34 | Multicopper ferroxidase | 2.63 | 0.75 | −1.05 |
| Galactose metabolism | |||||
| orf19.3675 | GAL7 | Galactose-1-phosphate uridyl transferase | −1.57 | 1.13 | 1.16 |
| orf19.3672 | GAL10 | UDP-glucose 4-epimerase | −1.47 | 1.59 | 1.83 |
| orf19.3670 | GAL1 | Galactokinase | −1.30 | 1.95 | 1.30 |
| Miscellaneous | |||||
| orf19.1691 | Uncharacterized | 6.33 | 2.45 | −1.71 | |
| orf19.3548.1 | WH11 | Cytoplasmic protein | 5.64 | 2.13 | 1.36 |
| orf19.2959.1 | Uncharacterized | 2.65 | 2.15 | 1.92 | |
| orf19.251 | ThiJ/PfpI protein family | 2.22 | 1.01 | 1.02 | |
| orf19.3932 | Uncharacterized | 2.09 | 1.80 | 2.40 | |
| orf19.675 | Similar to cell wall proteins | 2.03 | 1.30 | 1.25 | |
| orf19.260 | SLD1 | Sphingolipid Δ8 desaturase | 1.94 | 1.33 | −1.10 |
| orf19.7218 | RBE1 | Putative cell wall protein | 1.73 | −0.89 | −2.01 |
| orf19.5103 | Uncharacterized | 1.73 | −0.93 | −1.00 | |
| orf19.6117 | Uncharacterized | 1.68 | 0.93 | 1.10 | |
| orf19.4477 | CSH1 | Member of aldo-keto reductase family | 1.57 | 1.87 | 2.34 |
| orf19.4255 | ECM331 | GPI-anchored protein | 1.28 | 1.75 | 1.99 |
| orf19.6637 | Uncharacterized | 1.27 | 0.91 | 1.67 | |
| orf19.6877 | Uncharacterized | 1.19 | 1.35 | 1.34 | |
| orf19.2030 | Uncharacterized | 1.10 | 1.38 | 1.81 | |
| orf19.6554 | Uncharacterized | 1.01 | 1.43 | 1.95 | |
| orf19.4082 | DDR48 | Immunogenic stress-associated protein | 0.82 | 4.70 | 4.18 |
| orf19.999 | Uncharacterized | 0.79 | 1.08 | 1.08 | |
| orf19.4476 | Uncharacterized | 0.78 | 1.92 | 1.76 | |
| orf19.5125 | Uncharacterized | 0.67 | 1.38 | 1.59 | |
| orf19.4506 | LYS22 | Homocitrate synthase | −0.99 | 1.48 | 1.39 |
| orf19.4716 | GDH3 | NADP-glutamate dehydrogenase | −1.39 | 1.00 | 2.36 |
| orf19.670.2 | Uncharacterized | −3.12 | 1.32 | 1.30 | |