Table 4.
Genes with differential expression in a upc2Δ strain whose promoters are bound by Upc2
| Locus tag | Gene | Description | Mean log fold changea | Mean BRb |
|---|---|---|---|---|
| Downregulated genes | ||||
| Ergosterol biosynthesis | ||||
| orf19.391 | UPC2 | Transcriptional regulator of ergosterol biosynthetic genes | −5.14 | 1.90 |
| orf19.922 | ERG11 | Lanosterol 14-alpha-demethylase | −1.89 | 7.80 |
| orf19.1631 | ERG6 | Δ24-sterol C-methyltransferase | −1.88 | 2.90 |
| orf19.406 | ERG1 | Squalene epoxidase | −1.58 | 1.50 |
| orf19.6026 | ERG2 | C-8 sterol isomerase | −1.46 | 1.80 |
| orf19.5178 | ERG5 | Putative C-22 sterol desaturase | −1.45 | 3.95 |
| orf19.1591 | ERG10 | Acetyl coenzyme A acetyltransferase | −1.11 | 1.15 |
| orf19.1598 | ERG24 | C-14 sterol reductase | −0.74 | 1.65 |
| Multidrug transport | ||||
| orf19.5604 | MDR1 | Multidrug efflux pump of plasma membrane | −1.27 | 3.95 |
| Miscellaneous | ||||
| orf19.2251 | AAH1 | Similar to serine/threonine dehydratases | −1.80 | 1.60 |
| orf19.1996 | CHA1 | Uncharacterized | −1.79 | 1.70 |
| orf19.6090 | NSR1 | Uncharacterized | −1.71 | 1.70 |
| orf19.1691 | Uncharacterized | −1.71 | 3.95 | |
| orf19.1030 | FPR3 | Uncharacterized | −1.58 | 1.60 |
| orf19.5010 | DIM1 | Similar to S. cerevisiae Dim1p | −1.58 | 2.75 |
| orf19.3291 | HMT1 | Major type I protein arginine methyltransferases (PRMT) | −1.52 | 1.65 |
| orf19.18 | IMH3 | IMP dehydrogenase | −1.43 | 1.90 |
| orf19.2575 | Uncharacterized | −1.25 | 1.95 | |
| orf19.1901 | MCM3 | Uncharacterized | −1.13 | 1.60 |
| orf19.657 | SAM2 | S-adenosylmethionine synthetase | −1.04 | 2.25 |
| orf19.5066 | Uncharacterized | −1.03 | 1.85 | |
| orf19.496 | MSH1 | Uncharacterized | −1.02 | 1.50 |
| orf19.6253 | RPS23A | Ribosomal protein | −1.02 | 1.60 |
| orf19.2309.2 | RPL2B | Uncharacterized | −0.97 | 1.70 |
| orf19.4889 | HOL2 | Predicted membrane transporter | −0.94 | 10.75 |
| Upregulated genes | ||||
| orf19.2593 | BIO2 | Biotin synthase | 0.89 | 1.50 |
| orf19.6311 | Uncharacterized | 0.91 | 1.60 | |
| orf19.251 | ThiJ/PfpI protein family | 1.02 | 1.50 | |
| orf19.2699 | ABP1 | Protein similar to S. cerevisiae Abp1p | 1.03 | 1.70 |
| orf19.1789.1 | LYS1 | Mitochondrial homoisocitrate dehydrogenase | 1.06 | 1.60 |
| orf19.1307 | Uncharacterized | 1.07 | 1.50 | |
| orf19.4833 | MLS1 | Malate synthase | 1.09 | 1.60 |
| orf19.1350 | Uncharacterized | 1.16 | 18.50 | |
| orf19.1267 | CAJ1 | Uncharacterized | 1.17 | 1.65 |
| orf19.7204 | Uncharacterized | 1.23 | 2.20 | |
| orf19.4711 | Uncharacterized | 1.36 | 1.65 | |
| orf19.3282 | BMT3 | β-Mannosyltransferase | 1.49 | 1.90 |
| orf19.6840 | Uncharacterized | 1.85 | 1.70 |
a
Change in expression in a upc2Δ strain in hypoxia.
b
BR, binding ratio (from reference 91).