FIG. 1.

Modular architecture of EspF. (A) The different sizes of the four main EspF variants are determined by their number of proline-rich repeats (PRR), which are almost identical in size and sequence similarity. The EPEC and EHEC strains relate to E2348/69 and EDL933, respectively. (B) Phylogenetic tree of the N-terminal EspF region (residues 1 to 73) produced by using Clustal W software. Percent values indicate sequence identity relative to the EPEC variant. (C) Modular structure of the N-terminal region (residues 1 to 73) comprising the secretion signal, mitochondrial targeting signal (MTS), and nucleolar targeting domain. (D) Typical EspF PRR module taken from EPEC EspF, showing the host protein binding motifs; SNX9, sorting nexin 9.