FIG. 2.

The multiple functions of EspF. (A) Table listing all known functions of EspF in A/E pathogens as described in the text. The far-left column indicates whether evidence for the EspF function is direct (host cell expression or biochemical studies) or related to infection with EspF-deficient bacterial mutants. (B) Diagram of intestinal cells illustrating the varied functions and subcellular behavior of EspF. Parentheses indicate the host protein interaction predicted or proven to play a role in the indicated function.