TABLE 4.
Summary of the number of transcripts with differential expression within the major coexpression networks based on a stringent level of fold change in expression (>2-fold) or likelihood that the transcript is differentially expressed irrespective of the fold change (B value)
| Criterion | Comparison | No. of transcripts with altered expression in clustera: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCL1 | MCL2 | MCL3 | MCL4 | MCL5 | MCL6 | MCL7 | MCL8 | MCL9 | MCL10 | MCL11-259 | MCL260-577 | ||
| Tissue physiology and homeostasis (1,148) | Cellular immune responses (958) | Innate immunity (271) | Cell cycle (175) | Basic cell processes (174) | Keratinocyte cell biology (162) | Immunoglobulins (130) | Type II interferon signature (117) | Immunoglobulins (89) | Type I interferon response (88) | Epithelial cell barrier integrity (3,036) | Regulation of epithelial and conjunctiva-associated lymphoid tissue response with an inflammatory stimulus (1,371) | ||
| B ≥ 0 | N vs DI | 1,132 | 861 | 221 | 133 | 4 | 24 | 120 | 82 | 78 | 31 | 2,068 | 1,031 |
| N vs D | 874 | 207 | 146 | 1 | 5 | 1 | 45 | 2 | 1,163 | 521 | |||
| D vs DI | 277 | 359 | 4 | 136 | 2 | 106 | 34 | 9 | 464 | 243 | |||
| FC of <0.5 or >2.0; adjusted P < 0.01 | N vs DI | 368 | 402 | 112 | 20 | 19 | 74 | 42 | 54 | 9 | 455 | 440 | |
| N vs D | 49 | 25 | 55 | 1 | 1 | 1 | 24 | 1 | 97 | 99 | |||
| D vs DI | 6 | 2 | 65 | 17 | 2 | 81 | 75 | ||||||
a
Numbers in parentheses indicate the total number of transcripts in the cluster.