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A maximum-likelihood phylogenetic tree of full-length mammalian TRIM nucleotide sequences. (A) Hare and pika sequences fall within the TRIM5 cluster of the mammalian TRIM family, indicating that they are genuine TRIM5 orthologues. Branch lengths represent nucleotide substitutions per site. Percent bootstrap values (from 1,000 replicates) are shown on the branches. (B) Polymorphisms within the PRYSPRY sequences of four hares and six rabbits. Residues are numbered as in Fig. 2.
