FIG. 3.

Schematic representation of the hypothetical cellular consequences associated with CIHHV-6 (see text for details), as follows: (1) no viral gene transcription; (2) viral gene expression, replication, and virion production; (3) expression of a subset of HHV-6 genes; (4 and 5) impact of HHV-6 integration on telomere function, architecture, and chromosome stability; (6) trans and/or cis activation of cellular gene expression following integration; (7) immune tolerance due to expression of HHV-6 genes during embryogenesis; (8) destruction of tissues or cells expressing HHV-6 antigens (from integrated HHV-6) by immune defense mechanisms developed in response to natural HHV-6 infection.