TABLE 2.

The reaction network of the computational model

Step	Substrate(s)	Reaction	Product(s)	Ki+ (μM−1 min−1)a	Ki− (min−1)a	Source or reference
1	C3	→	Production and degradation	0.00039	0.0039	75 (estimated)
2	XIAP	→	Production and degradation	0.00116	0.0116	50 (estimated)
3	C3 + C3a	→	C3a + C3a	2.4	0	78 (estimated)
4	C3a + XIAP	↔	[XIAP∼C3a]	156	0.144	54
5	C3a + XIAP	→	C3a + BIR12	12	0	63
6	C3a + [XIAP∼C3a]	→	C3a + BIR12c3a	12	0	63
7	C3a + BIR12	⇆	BIR12∼C3a	156	0.144	54
8	BIR12	→	Degradation	0.0058	0	20
9	BIR12c3a	→	Degradation	0.0058	0	20
10	C3a	→	Degradation	0.0058	0	20
11	[XIAP∼C3a]	→	Degradation	0.0347	0	75
12	Substrate + C3a	→	C3a	12	0	63

^aKinetic constants refer to parameters for mass action kinetics for the forward (+) and backward (−) reactions.