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NHERF2 is necessary for stimulation of fluid absorption by LPA. (A) Effects of LPA on the rate of fluid absorption in Nherf2−/− (C57BL/6) mice under basal and CT-treated conditions are shown. Twenty micromolar LPA was added to the perfusion buffer when indicated. n = 6. ns, not significant. (B) To ascertain the lack of effect by LPA in Nherf2−/− (FVB/N) mice, 50 μM LPA was used. *P < . 05.
