Table 2.

Cognition and changes of Aβ between baseline and follow-ups in subjects

Baseline	Cognitively healthy		Cognitively impaired
N	59		11
Aβ40	195 (88)		201 (60)
Aβ42	50 (121)		46 (92)
Aβ42/Aβ40	0.236 (0.464)		0.291 (0.487)
	Cognitively stable or improved		Cognitive decline
Follow-up	3 years	6 years	3 years	6 years
N	43†	29‡	27	14
Change of Aβ40	18 (55)	33 (45)	21 (24)	33 (75)
Change of Aβ42	3.7 (29)	12 (54)	0.0 (14)*	−2.4(50)*
Change of Aβ42/Aβ40	0.0093 (0.169)	0.0166 (0.451)	−0.0027 (0.084)*	−0.0486 (0.251)*

Data are given as medians (IQR). The values of p reflect the significance against the cognitively stable subgroup.

^*p<0.05 against ‘stable or improved.’

^†Aβ data of one subject is from a plasma sample of 4 years of follow-up.

^‡Cognition data of two subjects is from the previous year.