Table II.

Simulation Results Based on 10,000 Realizations for Distribution 1

		Traditional Method		CRM with Escalation/De-escalation Decisions Based on Complete Cohorts		CRM with Escalation/De-escalation Decisions Based on Incomplete Cohorts
Dose	Actual Toxicity Probability	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage
1	5%	9.9% (2.5%)*	24.6%	4.1% (0.63%)*	20.8%	3.5% (0.58%)*	20.0%
2	10%	28.8%	27.2%	24.3%	29.5%	22.9%	28.5%
3	20%	38.3%	26.3%	46.8%	30.5%	47.9%	30.8%
4	35%	17.3%	16.2%	22.0%	15.5%	22.9%	16.4%
5	50%	3.2%	5.0%	2.1%	3.4%	2.2%	4.0%
6	70%	0.0%	0.7%	0.0	0.3%	0.04%	0.3%
Median Sample Size (Range)			18 (3–36)	15 (2–37)		16 (2–35)
Median % Toxicity (Range)			19.1%(5–67)	18.2% (0–100%)		18.8% (0–100%)
% of Trials Revisiting a Dose with ≥ 2 DLTs			-	14.5%		31.3%
% of Trials with ≥ 3 DLTs at a Dose			27%	15.4%		19.5%