Table V.

Simulation Results Based on 10,000 Realizations for Distribution 4

		Traditional Method		CRM with Escalation/De-escalation Decisions Based on Complete Cohorts		CRM with Escalation/De-escalation Decisions Based on Incomplete Cohorts
Dose	Actual Toxicity Probability	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage
1	1%	0.0%	14.9%	0.0%	13.2%	0.04%	12.9%
2	1%	2.6%	15.3%	0.8%	14.2%	0.9%	14.0%
3	5%	9.7%	17.8%	7.8%	18.4%	7.4%	18.3%
4	10%	39.1%	21.8%	40.5%	26.8%	40.6%	27.4%
5	25%	48.3%	22.5%	50.7%	22.6%	51.0%	22.8%
6	80%	0.0	7.8%	0.1%	4.8%	0.1%	4.8%
Median Sample Size (Range)			21 (6–33)	19 (3–40)			20 (3–42)
Median % Toxicity (Range)			14.3% (5–33%)	13.3% (6–67%)			13.6% (0–67%)
% of Trials Revisiting a Dose with ≥ 2 DLTs			-	10.2%			24.7%
% of Trials with ≥ 3 DLTs at a Dose			40.0%	18.7%			21.2%