Table VI.

Simulation Results Based on 10,000 Realizations for Distribution 5

		Traditional Method		CRM with Escalation/De-escalation Decisions Based on Complete Cohorts		CRM with Escalation/De-escalation Decisions Based on Incomplete Cohorts
Dose	Actual Toxicity Probability	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage	Percent Chosen	Experimentation Percentage
1	30%	32.5% (55.1%)*	74.3%	43.5% (28.4%)*	62.9%	44.8% (28.0)*	61.9%
2	40%	10.8%	20.5%	25.3%	30.9%	24.0%	30.5%
3	52%	1.7%	5.0%	2.6%	5.7%	3.1%	6.8%
4	61%	0%	0.6%	0.2%	0.5%	0.2%	0.8%
5	76%	0%	0.0%	0.0%	0.0%	0.0%	0.0%
6	87%	0%	0.0%	0.0%	0.0%	0.0%	0.0%
Median Sample Size (Range)			9 (3–27)	9 (2–26)		10 (2–29)
Median % Toxicity (Range)			33.3% (11–100%)	35.7% (11–100%)		37.5% (12–100%)
% of Trials Revisiting a Dose with ≥ 2 DLTs			-	24.7%		43.1%
% of Trials with ≥ 3 DLTs at a Dose			29.8%	29.1%		36.2%