FIG. 5.

Marker expression by grafted GFP-transgenic retinal progenitors. Following transplantation, GFP+ porcine RPCs in the subretinal space broadly expressed vimentin (A), while others located in the INL colabeled with GFAP (B), although labeling of donor profiles with this marker was limited (arrowheads). GFP+ processes exhibited a tropism for the synaptic layers of the retina and colabeled extensively with synaptobrevin within them (C). Grafted cells expressed the photoreceptor markers rhodopsin (D) and transducin (E) in the subretinal space, although this appeared to be associated with limited GFP coexpression for both markers (arrowheads). (See paper online for Fig. 5 in color.)