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. Author manuscript; available in PMC: 2011 Apr 14.
Published in final edited form as: N Engl J Med. 2010 Sep 8;363(16):1532–1543. doi: 10.1056/NEJMoa1008433

Figure 2. Results of Immunohistochemical Analyses of BAF250a Expression.

Figure 2

The percentages of tumors (with number and total number in parentheses) from three subtypes of ovarian cancer — clear-cell carcinoma (CCC), endometrioid carcinoma (EC), and high-grade serous (HGS) carcinoma — from the discovery and mutation-validation cohorts that showed loss of BAF250a expression are shown in Panel A for samples with and samples without ARID1A mutations and in Panel B for samples in the discovery and mutation-validation cohorts and samples in the immunohistochemical validation cohort. The rate of BAF250a loss was higher among CCC specimens with an ARID1A mutation than among those without an ARID1A mutation (P<0.001); the same was true for EC specimens (P = 0.02). The loss of expression was also consistently more common in CCC and EC (the two endometriosis-associated carcinomas) than in HGS carcinoma when assessed in the discovery and mutation-validation cohorts and again in the immunohistochemical validation cohort (Panel B), with P<0.001 for all comparisons. All P values were calculated with the use of Fisher’s exact test.