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. 2010 Nov 9;4(11):e866. doi: 10.1371/journal.pntd.0000866

Figure 6. Development of cell-mediated immune response as disclosed by in vivo depletion with anti-CD4+ and anti-CD8+ monoclonal antibodies.

Figure 6

Leishmania chagasi parasite-load (A and B) and percent of liver/corporal relative weight (C and D) in mice vaccinated with NH36sap and F3 sap vaccine and treated with rat serum, anti-CD4+ or anti-CD8+ or the combination of anti-CD4+ and anti-CD8+ MAbs. Maximal parasite load reduction was achieved in mice that received either the NH36sap or the F3sap vaccines and rat serum (rat IgG) as controls for antibody treatment. Bars represent the mean + SD (5 mice per each treatment). The parasite load is expressed in LDU values (number of amastigotes per 600 liver cell nuclei/mg of liver weight) (A and B). Hepatomegaly was assessed by the individual increment in liver relative weight expressed as percent of the body weight. + p<0.05 significant differences between treatments.