Table 3. Superiority of the F3 over the NH36 vaccine.
Variable | F3 | NH36 | Enrichment |
IDR 24 h after immunization | 0.262 | 0.178 | 32.06% |
IDR 48 h after immunization | 0.173 | 0.114 | 34.10% |
IDR 48 h after challenge | 0.243 | 0.191 | 21.40% |
Ratio IFN-γ/IL-10 CD4 T cells | 1.23 | 0.77 | 37.39% |
Reduction of parasite load (in vivo depletion) | 90.5 | 65.90 | 27.18% |
Reduction of parasite load L chagasi | 88.23 | 37.06 | 57.99% |
Reduction of parasite load L. amazonensis | 100 | 53.00 | 47.00% |
Mean + SD | 36.73+12.33% |
Calculation was performed according the following equation = (F3-NH36/F3) values x 100 = protective effect increment.