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. Author manuscript; available in PMC: 2010 Nov 9.
Published in final edited form as: Clin Pharmacol Ther. 2007 Jul 4;83(2):273–280. doi: 10.1038/sj.clpt.6100275

Figure 2.

Figure 2

The effect of OCT1 polymorphisms on the pharmacokinetic parameters of oral metformin. (a) AUCB (AUC normalized to the second dose of 1,000mg); (b) V/F (oral volume of distribution; volume of distribution divided by oral bioavailability); (c) CL/F (oral clearance; clearance divided by oral bioavailability). The lines represent mean values for the two groups. *P<0.025, **P<0.005, difference between the two genotype groups, unpaired Student’s t-test.