Table 4.
Metformin pharmacokinetic parameters from Oct1+/+ and Oct1−/− mice.
|
0ct1+/+ (n=5) |
Octl−/− (n=6) |
|||
|---|---|---|---|---|
| Mean | SD | Mean | SD | |
| T1/2 (h) | 5.5 | 2.0 | 5.4 | 1.7 |
| AUC0–1 h (μg h/ml) | 3.1 | 0.57 | 4.0* | 0.73 |
| AUC0–24h (μg h/ml) | 19.0 | 1.9 | 21.8 | 2.5 |
| V/F (ml) | 356 | 200 | 187 | 75 |
| CL/F (ml/h) | 29.7 | 6.0 | 23.6 | 4.5 |
| Urine recovery (%) | 60 | 7 | 50 | 13 |
| Feces recovery (%) | 30 | 10 | 29 | 3 |
AUC, area under the curve of blood concentration–time of metformin; CL/F, oral clearance (clearance over oral bioavailability); T1/2, half-life; V/F, oral volume of distribution (volume of distribution over oral bioavailability). The mice were given an oral dose of metformin (15mg/kg containing 0.2mCi/kg of 14C-metformin), approximating the single dose of 1,000mg in humans. The radioactivity in blood was determined and converted to mass amounts.
*
P=0.05 compared with Oct1+/+/ mice