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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Pharmacogenet Genomics. 2010 Nov;20(11):687–699. doi: 10.1097/FPC.0b013e32833fe789

Figure 3. Uptake of various endogenous amines and MPP+ in HEK293 cells stably expressing OCT3 and 6 missense variants.

Figure 3

Figure 3

A. The time course of uptake of monoamines and MPP+. B. Substrate selectivity of genetic variants of OCT3 on model substrate and monoamines. Data are shown as mean ± SD from 3 repeated experiments and each experiment was performed in triplicate. OCT3-reference is used as control set at 100% for each substrate. **p<0.01 versus OCT3 – reference.