Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model for α-TEA-induced ASMase/ceramide dependent apoptosis. The model depicts α-TEA induction of ASMase translocation from cytosol (lysosomes) to the cell surface membrane and the generation of ceramide from hydrolysis of sphingomyelin as an early event (4 hrs) and the colocalization of DR5, Fas, and FADD with ceramide and induction of apoptosis as the cell fate (9-15 hrs). ASMase inhibitor desipramine or ASMase siRNA block α-TEA-initiated events.
