Table 3.
Cancers in which Jab1/CSN5 is overexpressed and its association with p27 and clinical outcome
| Tumor type | Associated with poor outcome | Negative Correlation with p27 | References |
|---|---|---|---|
| Pituitary tumor | No | Yes | [121] |
| Pancreatic adenocarcinoma | Yes | Yes | [100,122] |
| Oral squamous cell carcinoma | Yes | Yes | [123,124] |
| Epithelial ovarian tumors | Yes | Yes | [125,126] |
| Neuroblastoma | ND | ND | [127] |
| Embryonal rhabdomyosarcoma | No | Yes | [128] |
| Hepatocellular carcinoma | ND | Yes | [83,97,107] |
| Intrahepatic Cholangiocarcinomas | No | No | [129] |
| Laryngeal squamous cell carcinoma | Yes | Yes | [130] |
| Esophageal squamous cell carcinoma | Yes | Yes | [131] |
| Metastatic melanoma | ND | Yes | [132] |
| Invasive breast carcinoma | Yes | Yes | [92,93] |
| ERalpha-negative breast cancer | No | No | [98] |
| Systemic anaplastic large cell lymphoma | ND | Yes | [133] |
| Non-Hodgkin's lymphoma | Yes | Yes | [134] |
| Malignant lymphoma of the thyroid | ND | Yes | [135] |
| Thyroid medullary carcinoma | No | Yes | [136] |
| Papillary Thyroid Carcinoma | Yes | ND | [137] |
| Non-small-cell lung cancer | Yes | Yes | [138,139] |
Abbreviation: ND, not determined