Table 1.

Annotations enriched in differentially coexpressed modules

Module	Category	Subcategory	Expected		Observed	fdr
Black	KEGG	Metabolism of xenobiotics by cytochrome P450	1.367		12	<0.001
	KEGG	Metabolic pathways	22.494		40	<0.001
	GO	Glutathione transferase activity	0.364		9	<0.001
Blue	KEGG	Lysosome	3.373		12	0.008
	KEGG	Metabolic pathways	31.541		48	0.026
	GO	Mitochondrion	35.764		67	<0.001
Brown	GO	Intracellular transport	8.481		22	0.038
Green	GO	Mitochondrion	10.234		26	0.003
	GO	Oxidation reduction	4.015		15	0.003
Orange	GO	Xenobiotic metabolic process	0.079		5	<0.001
Purple	No significant enrichment
Red	KEGG	Endometrial cancer	0.201		3	0.015
Yellow	KEGG	Pancreatic cancer	3.344		14	<0.001
	KEGG	Renal cell carcinoma	3.702		10	0.043
	KEGG	Pathways in cancer	14.75		27	0.022
	GO	Protein localization	33.676		64	<0.001
	GO	Melanosome	2.995		11	0.009
	GO	Cell projection	33.886		59	0.002
	GO	Small GTPase mediated signal transduction	14.342		31	0.003

Selected annotations enriched among the genes of each differentially coexpressed modules and associated false discovery rates (fdr). The over-representation analysis was conducted using GeneTrail. The complete results are available in Additional File 3.