Table 1.
Properties of MDR families
| ID | Name | Size | Swiss-Prot | PCID Avg (StdDev) | Eukaryotic | Bacterial | Archaeal |
|---|---|---|---|---|---|---|---|
| MDR001 | ADH | 2217 | 116 | 51.24 (19.02) | 1315 (59.3%) | 895 (40.4%) | 6 (0.3%) |
| MDR002 | PTGR | 774 | 17 | 42.46 (9.64) | 253 (32.7%) | 518 (66.9%) | 3 (0.4%) |
| MDR003 | FAS | 706 | 11 | 39.07 (9.88) | 288 (40.8%) | 418 (59.2%) | 0 (0.0%) |
| MDR004 | QORX | 486 | 1 | 47.47 (10.07) | 69 (14.2%) | 417 (85.8%) | 0 (0.0%) |
| MDR005 | PDH | 328 | 18 | 45.59 (11.81) | 181 (55.2%) | 146 (44.5%) | 1 (0.3%) |
| MDR006 | ZADH2 | 56 | 4 | 51.49 (15.19) | 51 (91.1%) | 5 (8.9%) | 0 (0.0%) |
| MDR007 | MECR | 51 | 9 | 54.60 (13.15) | 51 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR008 | VAT1 | 50 | 6 | 60.49 (19.60) | 48 (96.0%) | 2 (4.0%) | 0 (0.0%) |
| MDR009 | vertQOR | 22 | 8 | 70.12 (10.34) | 21 (95.5%) | 1 (4.5%) | 0 (0.0%) |
| MDR010 | CAD | 661 | 32 | 49.08 (10.02) | 329 (49.8%) | 330 (49.9%) | 2 (0.3%) |
| MDR011 | bpQOR | 575 | 5 | 47.93 (11.86) | 66 (11.5%) | 509 (88.5%) | 0 (0.0%) |
| MDR012 | YHDH | 481 | 2 | 53.92 (11.43) | 1 (0.2%) | 477 (99.2%) | 0 (0.0%) |
| MDR013 | FDH | 375 | 4 | 47.16 (12.56) | 29 (7.7%) | 346 (92.3%) | 0 (0.0%) |
| MDR014 | TDH | 351 | 126 | 69.40 (16.11) | 1 (0.3%) | 343 (97.7%) | 7 (2.0%) |
| MDR015 | QORL2 | 319 | 4 | 45.25 (8.76) | 38 (11.9%) | 281 (88.1%) | 0 (0.0%) |
| MDR016 | bADH | 313 | 17 | 60.72 (15.62) | 1 (0.3%) | 312 (99.7%) | 0 (0.0%) |
| MDR017 | 279 | 8 | 51.97 (8.93) | 2 (0.7%) | 277 (99.3%) | 0 (0.0%) | |
| MDR018 | 194 | 1 | 47.22 (10.60) | 48 (24.7%) | 146 (75.3%) | 0 (0.0%) | |
| MDR019 | 136 | 0 | 60.51 (12.37) | 18 (13.2%) | 118 (86.8%) | 0 (0.0%) | |
| MDR020 | yADH | 128 | 22 | 63.56 (12.11) | 128 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR021 | YJGB | 122 | 1 | 69.98 (20.96) | 2 (1.6%) | 120 (98.4%) | 0 (0.0%) |
| MDR022 | giFDH | 122 | 2 | 63.32 (18.53) | 5 (4.1%) | 111 (91.0%) | 6 (4.9%) |
| MDR023 | 72 | 5 | 52.93 (17.12) | 10 (13.9%) | 56 (77.8%) | 6 (8.3%) | |
| MDR024 | 40 | 0 | 52.66 (11.72) | 7 (17.5%) | 32 (80.0%) | 1 (2.5%) | |
| MDR025 | yPDH | 34 | 0 | 65.44 (13.11) | 34 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR026 | yDH | 34 | 0 | 60.48 (13.13) | 34 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR027 | QORH | 34 | 2 | 60.28 (10.85) | 34 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR028 | 29 | 0 | 55.36 (9.11) | 1 (3.4%) | 28 (96.6%) | 0 (0.0%) | |
| MDR029 | yADH2 | 29 | 1 | 59.02 (15.24) | 29 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR030 | dFAS | 28 | 0 | 57.51 (16.34) | 28 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR031 | yDH2 | 28 | 0 | 53.43 (12.87) | 28 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR032 | bADH2 | 26 | 0 | 69.59 (17.08) | 1 (3.8%) | 25 (96.2%) | 0 (0.0%) |
| MDR033 | yBDH | 23 | 2 | 54.51 (12.62) | 23 (100.0%) | 0 (0.0%) | 0 (0.0%) |
| MDR034 | 23 | 0 | 54.57 (14.09) | 13 (56.5%) | 10 (43.5%) | 0 (0.0%) | |
| MDR035 | 22 | 0 | 47.17 (10.55) | 22 (100.0%) | 0 (0.0%) | 0 (0.0%) | |
| MDR036 | bADH3 | 21 | 4 | 50.26 (15.82) | 1 (4.8%) | 12 (57.1%) | 8 (38.1%) |
| MDR037 | 20 | 0 | 66.14 (13.09) | 20 (100.0%) | 0 (0.0%) | 0 (0.0%) | |
| MDR038 | 20 | 0 | 74.56 (12.47) | 20 (100.0%) | 0 (0.0%) | 0 (0.0%) | |
| MDR039 | bADH4 | 150 | 0 | 58.99 (10.83) | 0 (0.0%) | 150 (100.0%) | 0 (0.0%) |
| MDR040 | SORE | 117 | 2 | 61.62 (21.91) | 0 (0.0%) | 117 (100.0%) | 0 (0.0%) |
| MDR041 | BurkDH | 114 | 0 | 63.89 (15.74) | 0 (0.0%) | 114 (100.0%) | 0 (0.0%) |
| MDR042 | YJJN | 114 | 1 | 57.50 (18.31) | 0 (0.0%) | 114 (100.0%) | 0 (0.0%) |
| MDR043 | IDND | 96 | 1 | 55.99 (17.90) | 0 (0.0%) | 96 (100.0%) | 0 (0.0%) |
| MDR044 | 96 | 0 | 54.24 (13.62) | 0 (0.0%) | 92 (95.8%) | 4 (4.2%) | |
| MDR045 | 89 | 0 | 56.57 (14.09) | 0 (0.0%) | 89 (100.0%) | 0 (0.0%) | |
| MDR046 | RSPB | 78 | 1 | 72.88 (16.80) | 0 (0.0%) | 78 (100.0%) | 0 (0.0%) |
| MDR047 | 72 | 0 | 58.49 (18.18) | 0 (0.0%) | 72 (100.0%) | 0 (0.0%) | |
| MDR048 | GATD | 71 | 2 | 83.33 (14.94) | 0 (0.0%) | 71 (100.0%) | 0 (0.0%) |
| MDR049 | 69 | 0 | 54.89 (14.55) | 0 (0.0%) | 69 (100.0%) | 0 (0.0%) | |
| MDR050 | CCR | 67 | 0 | 72.88 (15.83) | 0 (0.0%) | 67 (100.0%) | 0 (0.0%) |
| MDR051 | TARJ | 63 | 1 | 60.87 (21.70) | 0 (0.0%) | 62 (98.4%) | 1 (1.6%) |
| MDR052 | YCJQ | 48 | 2 | 91.08 (10.57) | 0 (0.0%) | 48 (100.0%) | 0 (0.0%) |
| MDR053 | 48 | 0 | 50.84 (14.22) | 0 (0.0%) | 48 (100.0%) | 0 (0.0%) | |
| MDR054 | YDJL | 46 | 1 | 93.70 (12.44) | 0 (0.0%) | 46 (100.0%) | 0 (0.0%) |
| MDR055 | 44 | 0 | 63.84 (10.29) | 0 (0.0%) | 44 (100.0%) | 0 (0.0%) | |
| MDR056 | 44 | 0 | 63.41 (20.64) | 0 (0.0%) | 44 (100.0%) | 0 (0.0%) | |
| MDR057 | BCHC | 43 | 2 | 61.89 (8.07) | 0 (0.0%) | 43 (100.0%) | 0 (0.0%) |
| MDR058 | 43 | 0 | 76.53 (11.52) | 0 (0.0%) | 43 (100.0%) | 0 (0.0%) | |
| MDR059 | 42 | 0 | 56.97 (9.37) | 0 (0.0%) | 42 (100.0%) | 0 (0.0%) | |
| MDR060 | YPHC | 42 | 1 | 84.08 (22.01) | 0 (0.0%) | 42 (100.0%) | 0 (0.0%) |
| MDR061 | bBDH | 40 | 0 | 63.33 (22.56) | 0 (0.0%) | 40 (100.0%) | 0 (0.0%) |
| MDR062 | CCR2 | 40 | 0 | 73.01 (14.76) | 0 (0.0%) | 40 (100.0%) | 0 (0.0%) |
| MDR063 | 38 | 0 | 58.21 (20.04) | 0 (0.0%) | 38 (100.0%) | 0 (0.0%) | |
| MDR064 | 33 | 0 | 81.63 (18.31) | 0 (0.0%) | 33 (100.0%) | 0 (0.0%) | |
| MDR065 | 32 | 0 | 53.79 (11.72) | 0 (0.0%) | 31 (96.9%) | 1 (3.1%) | |
| MDR066 | 32 | 1 | 82.45 (18.25) | 0 (0.0%) | 32 (100.0%) | 0 (0.0%) | |
| MDR067 | bQOR | 32 | 0 | 73.92 (21.12) | 0 (0.0%) | 32 (100.0%) | 0 (0.0%) |
| MDR068 | 32 | 0 | 55.05 (10.93) | 0 (0.0%) | 32 (100.0%) | 0 (0.0%) | |
| MDR069 | 32 | 0 | 54.76 (13.41) | 0 (0.0%) | 30 (93.8%) | 2 (6.2%) | |
| MDR070 | 31 | 0 | 50.14 (19.08) | 0 (0.0%) | 31 (100.0%) | 0 (0.0%) | |
| MDR071 | 31 | 0 | 52.17 (11.37) | 0 (0.0%) | 31 (100.0%) | 0 (0.0%) | |
| MDR072 | bDHSO | 31 | 1 | 65.28 (20.13) | 0 (0.0%) | 31 (100.0%) | 0 (0.0%) |
| MDR073 | bQOR2 | 31 | 0 | 81.84 (19.40) | 0 (0.0%) | 31 (100.0%) | 0 (0.0%) |
| MDR074 | 30 | 0 | 79.07 (19.18) | 0 (0.0%) | 30 (100.0%) | 0 (0.0%) | |
| MDR075 | 29 | 0 | 82.92 (18.37) | 0 (0.0%) | 29 (100.0%) | 0 (0.0%) | |
| MDR076 | 29 | 0 | 57.41 (13.46) | 0 (0.0%) | 29 (100.0%) | 0 (0.0%) | |
| MDR077 | 28 | 0 | 58.92 (10.41) | 0 (0.0%) | 24 (85.7%) | 4 (14.3%) | |
| MDR078 | RhobDH | 25 | 0 | 55.27 (11.23) | 0 (0.0%) | 25 (100.0%) | 0 (0.0%) |
| MDR079 | 25 | 0 | 63.69 (12.82) | 0 (0.0%) | 25 (100.0%) | 0 (0.0%) | |
| MDR080 | bPDH | 24 | 0 | 75.24 (15.12) | 0 (0.0%) | 24 (100.0%) | 0 (0.0%) |
| MDR081 | 23 | 0 | 53.96 (19.57) | 0 (0.0%) | 23 (100.0%) | 0 (0.0%) | |
| MDR082 | 23 | 0 | 63.98 (10.48) | 0 (0.0%) | 23 (100.0%) | 0 (0.0%) | |
| MDR083 | 21 | 0 | 57.76 (20.40) | 0 (0.0%) | 9 (42.9%) | 12 (57.1%) | |
| MDR084 | 21 | 0 | 44.68 (12.83) | 0 (0.0%) | 21 (100.0%) | 0 (0.0%) | |
| MDR085 | 21 | 0 | 68.74 (15.71) | 0 (0.0%) | 21 (100.0%) | 0 (0.0%) | |
| MDR086 | MycDH | 20 | 0 | 65.99 (28.08) | 0 (0.0%) | 20 (100.0%) | 0 (0.0%) |
This table shows properties of the MDR families for which we have derived HMMs, including its assigned name (if any), size, number of members in the Swiss-Prot database, average percent pairwise sequence identities in the family (and sample standard deviation) and distribution of members over the kingdoms of life (and proportions). See also Additional file 2: mdr-properties for further data. Empty name fields indicate families where the function has not yet been established for any of the members.