Table 1.
Characteristics of women with early stage breast cancer (0, I, II) and their outcomes
| Total (17,286) |
Women with no second breast cancer (N = 16,628) |
Breast cancer recurrencea total (N = 314) |
Second primary breast cancer total (N = 344) |
|||||
|---|---|---|---|---|---|---|---|---|
| N | Row % | N | Row % | N | Row % | |||
| Characteristics of 1st cancer diagnosis | ||||||||
| Stage at 1st diagnosis | ||||||||
| 0 | 3,243 | 18.8 | 3,071 | 94.7 | 92 | 2.8 | 80 | 2.5 |
| I | 8,327 | 48.2 | 8,050 | 96.7 | 110 | 1.3 | 167 | 2.0 |
| IIA | 3,797 | 22.0 | 3,680 | 96.9 | 68 | 1.8 | 49 | 1.3 |
| IIB | 1,919 | 11.1 | 1,827 | 95.2 | 44 | 2.3 | 48 | 2.5 |
| Nodal status | ||||||||
| No invasion | 10,565 | 61.1 | 10,215 | 96.7 | 157 | 1.5 | 193 | 1.8 |
| Invasion | 3,476 | 20.1 | 3,340 | 96.1 | 65 | 1.9 | 71 | 2.0 |
| Unknown | 3,245 | 18.8 | 3,073 | 94.7 | 92 | 2.8 | 80 | 2.5 |
| Hormone receptor | ||||||||
| ER−/PR− | 2,097 | 12.1 | 1,994 | 95.1 | 60 | 2.9 | 43 | 2.1 |
| ER−/PR+ | 215 | 1.2 | 205 | 95.3 | 8 | 3.7 | 2 | 0.9 |
| ER+/PR− | 1,310 | 7.6 | 1,270 | 96.9 | 24 | 1.8 | 16 | 1.2 |
| ER+/PR+ | 9,131 | 52.8 | 8,861 | 97.0 | 109 | 1.2 | 161 | 1.8 |
| Unknown | 4,533 | 26.2 | 4,298 | 94.8 | 113 | 2.5 | 122 | 2.7 |
| Primary surgery | ||||||||
| BCS without radiation therapy | 3,150 | 18.2 | 2,971 | 94.3 | 120 | 3.8 | 59 | 1.9 |
| BCS with radiation therapy | 7,962 | 46.1 | 7,689 | 96.6 | 118 | 1.5 | 155 | 1.9 |
| Mastectomy | 6,174 | 35.7 | 5,968 | 96.7 | 76 | 1.2 | 130 | 2.1 |
| Radiation therapy | ||||||||
| None | 8,128 | 47.0 | 7,790 | 95.8 | 185 | 2.3 | 153 | 1.9 |
| Any | 8,944 | 51.7 | 8,637 | 96.6 | 128 | 1.4 | 179 | 2.0 |
| Unknown | 214 | 1.2 | 201 | 93.9 | 1 | 0.5 | 12 | 5.6 |
| Adjuvant therapy | ||||||||
| Neither | 8,388 | 48.5 | 8,038 | 95.8 | 170 | 2.0 | 180 | 2.1 |
| Chemotherapy | 2,496 | 14.4 | 2,380 | 95.4 | 61 | 2.4 | 55 | 2.2 |
| Hormonal | 3,744 | 21.7 | 3,636 | 97.1 | 47 | 1.3 | 61 | 1.6 |
| Both | 1,649 | 9.5 | 1,592 | 96.5 | 27 | 1.6 | 30 | 1.8 |
| Unknown | 1,009 | 5.8 | 982 | 97.3 | 9 | 0.9 | 18 | 1.8 |
| Mode of detection of 1st cancer diagnosis | ||||||||
| Screen-detected (screen and positive) | 6,183 | 35.8 | 5,984 | 96.8 | 87 | 1.4 | 112 | 1.8 |
| Screen interval-detected (screen and negative) | 2,702 | 15.6 | 2,597 | 96.1 | 44 | 1.6 | 61 | 2.3 |
| Diagnostic detected (diagnostic and positive) | 3,389 | 19.6 | 3,242 | 95.7 | 77 | 2.3 | 70 | 2.1 |
| Diagnostic interval-detected (diagnostic and negative) | 953 | 5.5 | 912 | 95.7 | 19 | 2.0 | 22 | 2.3 |
| Unknown | 4,059 | 23.5 | 3,893 | 95.9 | 87 | 2.1 | 79 | 1.9 |
| Characteristics of women at 1st cancer diagnosis | ||||||||
| Age at 1st diagnosis | ||||||||
| 18–39 | 710 | 4.1 | 668 | 94.1 | 25 | 3.5 | 17 | 2.4 |
| 40–49 | 3,411 | 19.7 | 3,253 | 95.4 | 87 | 2.6 | 71 | 2.1 |
| 50–59 | 4,616 | 26.7 | 4,452 | 96.4 | 78 | 1.7 | 86 | 1.9 |
| 60–69 | 3,864 | 22.4 | 3,732 | 96.6 | 57 | 1.5 | 75 | 1.9 |
| 70–79 | 3,291 | 19.0 | 3,164 | 96.1 | 50 | 1.5 | 77 | 2.3 |
| ≥80 | 1,394 | 8.1 | 1,359 | 97.5 | 17 | 1.2 | 18 | 1.3 |
| Year of 1st diagnosis | ||||||||
| 1996–1997 | 3,322 | 19.2 | 3,165 | 95.3 | 73 | 2.2 | 84 | 2.5 |
| 1998–1999 | 3,789 | 21.9 | 3,598 | 95.0 | 88 | 2.3 | 103 | 2.7 |
| 2000–2001 | 3,784 | 21.9 | 3,607 | 95.3 | 83 | 2.2 | 94 | 2.5 |
| 2002–2003 | 3,458 | 20.0 | 3,364 | 97.3 | 46 | 1.3 | 48 | 1.4 |
| 2004–2006 | 2,933 | 17.0 | 2,894 | 98.7 | 24 | 0.8 | 15 | 0.5 |
| Race/ethnicity | ||||||||
| White | 13,178 | 76.2 | 12,686 | 96.3 | 227 | 1.7 | 265 | 2.0 |
| Black | 132 | 0.8 | 124 | 93.9 | 5 | 3.8 | 3 | 2.3 |
| Hispanic | 1,884 | 10.9 | 1,823 | 96.8 | 39 | 2.1 | 22 | 1.2 |
| Asian/Pacific Islander | 242 | 1.4 | 233 | 96.3 | 2 | 0.8 | 7 | 2.9 |
| Native American | 303 | 1.8 | 293 | 96.7 | 8 | 2.6 | 2 | 0.7 |
| Other | 195 | 1.1 | 184 | 94.4 | 7 | 3.6 | 4 | 2.1 |
| Unknown | 1,352 | 7.8 | 1,285 | 95.0 | 26 | 1.9 | 41 | 3.0 |
| Menopausal status (≤6 months of diagnosis) | ||||||||
| Pre-menopausal | 2,485 | 14.4 | 2,377 | 95.7 | 57 | 2.3 | 51 | 2.1 |
| Post-menopausal | 9,757 | 56.4 | 9,435 | 96.7 | 142 | 1.5 | 180 | 1.8 |
| Unknown | 5,044 | 29.2 | 4,816 | 95.5 | 115 | 2.3 | 113 | 2.2 |
| 1st degree family history of breast cancer (before 1st diagnosis) | ||||||||
| No | 11,247 | 65.1 | 10,855 | 96.5 | 195 | 1.7 | 197 | 1.8 |
| Yes | 2,881 | 16.7 | 2,764 | 95.9 | 46 | 1.6 | 71 | 2.5 |
| Unknown | 3,158 | 18.3 | 3,009 | 95.3 | 73 | 2.3 | 76 | 2.4 |
| Breast density (before 1st diagnosis and within 2 years of mammogram used for mode of detection) | ||||||||
| Almost entirely fatty | 493 | 2.9 | 480 | 97.4 | 11 | 2.2 | 2 | 0.4 |
| Scattered fibroglandular | 3,900 | 22.6 | 3,771 | 96.7 | 65 | 1.7 | 64 | 1.6 |
| Heterogeneously dense | 4,275 | 24.7 | 4,109 | 96.1 | 58 | 1.4 | 108 | 2.5 |
| Extremely dense | 930 | 5.4 | 885 | 95.2 | 21 | 2.3 | 24 | 2.6 |
| Unknown | 7,688 | 44.5 | 7,383 | 96.0 | 159 | 2.1 | 146 | 1.9 |
BCS breast conserving surgery, ER estrogen receptor, PR progesterone receptor
a
Recurrent cancer includes a 2nd cancer in the same breast and with the same histology as the initial cancer