Table 2.
Rates (per 1,000 woman years) of breast cancer recurrences and second primaries by characteristics at initial diagnosis
| Breast cancer recurrencesa | Second breast primaries | |||||
|---|---|---|---|---|---|---|
| N | Rates | 95% CI | N | Rates | 95% CI | |
| Characteristics of 1st cancer diagnosis and treatment | ||||||
| Stage at 1st diagnosis | ||||||
| 0 | 92 | 8.5 | (6.8, 10.4) | 80 | 7.4 | (5.8, 9.2) |
| I | 110 | 3.9 | (3.2, 4.7) | 167 | 5.9 | (5.0, 6.8) |
| IIA | 68 | 5.3 | (4.1, 6.7) | 49 | 3.8 | (2.8, 5.0) |
| IIB | 44 | 7.1 | (5.2, 9.5) | 48 | 7.8 | (5.7, 10.3) |
| Nodal status | ||||||
| No invasion | 157 | 4.4 | (3.7, 5.1) | 193 | 5.3 | (4.6, 6.2) |
| Invasion | 65 | 5.7 | (4.4, 7.2) | 71 | 6.2 | (4.8, 7.8) |
| Hormone receptor | ||||||
| ER−/PR− | 60 | 9.0 | (6.9, 11.6) | 43 | 6.4 | (4.7, 8.7) |
| ER−/PR+ | 8 | 10.8 | (4.7, 21.3) | 2 | 2.7 | (0.3, 9.8) |
| ER+/PR− | 24 | 5.5 | (3.5, 8.2) | 16 | 3.7 | (2.1, 6.0) |
| ER+/PR+ | 109 | 3.6 | (2.9, 4.3) | 161 | 5.3 | (4.5, 6.2) |
| Treatment | ||||||
| BCS without radiation therapy | 120 | 12.7 | (10.6, 15.2) | 59 | 6.3 | (4.8, 8.1) |
| BCS with radiation therapy | 118 | 4.2 | (3.5, 5.1) | 155 | 5.5 | (4.7, 6.5) |
| BCS with and without radiation therapy | 238 | 6.4 | (5.6, 7.2) | 214 | 5.7 | (5.0, 6.5) |
| Mastectomy | 76 | 3.6 | (2.8, 4.5) | 130 | 6.2 | (5.2, 7.3) |
| Adjuvant therapy | ||||||
| Neither | 170 | 6.1 | (5.3, 7.1) | 180 | 6.5 | (5.6, 7.5) |
| Chemotherapy | 61 | 7.2 | (5.5, 9.3) | 55 | 6.5 | (4.9, 8.5) |
| Hormonal | 47 | 3.5 | (2.5, 4.6) | 61 | 4.5 | (3.4, 5.8) |
| Both | 27 | 4.4 | (2.9, 6.4) | 30 | 4.9 | (3.3, 6.9) |
| Mode of 1st cancer diagnosis | ||||||
| Screen-detected | 87 | 4.1 | (3.3, 5.1) | 112 | 5.3 | (4.4, 6.4) |
| Screen interval | 44 | 4.8 | (3.5, 6.4) | 61 | 6.6 | (5.1, 8.5) |
| Diagnostic detected | 77 | 6.8 | (5.4, 8.6) | 70 | 6.2 | (4.8, 7.9) |
| Diagnostic interval | 19 | 5.9 | (3.6, 9.2) | 22 | 6.8 | (4.3, 10.3) |
| Unknown | 87 | 6.3 | (5.1, 7.8) | 79 | 5.8 | (4.6, 7.2) |
| Characteristics of women at 1st cancer diagnosis | ||||||
| Age at 1st diagnosis | ||||||
| 18–39 | 25 | 9.7 | (6.3, 14.4) | 17 | 6.6 | (3.9, 10.6) |
| 40–49 | 87 | 7.4 | (5.9, 9.1) | 71 | 6.0 | (4.7, 7.6) |
| 50–59 | 78 | 5.0 | (3.9, 6.2) | 86 | 5.5 | (4.4, 6.8) |
| 60–69 | 57 | 4.3 | (3.3, 5.6) | 75 | 5.7 | (4.5, 7.1) |
| 70–79 | 50 | 4.6 | (3.4, 6.0) | 77 | 7.0 | (5.5, 8.8) |
| ≥80 | 17 | 4.0 | (2.3, 6.4) | 18 | 4.2 | (2.5, 6.7) |
| Race/ethnicity | ||||||
| White | 227 | 5.1 | (4.5, 5.8) | 265 | 5.9 | (5.3, 6.7) |
| Black | 5 | 11.2 | (3.6, 26.1) | 3 | 6.7 | (1.4, 19.6) |
| Hispanic | 39 | 6.3 | (4.5, 8.6) | 22 | 3.6 | (2.2, 5.4) |
| Asian/Pacific Islander | 2 | 2.5 | (0.3, 9.1) | 7 | 8.8 | (3.5, 18.1) |
| Native American | 8 | 7.9 | (3.4, 15.6) | 2 | 2.0 | (0.2, 7.1) |
| Other | 7 | 10.9 | (4.4, 22.5) | 4 | 6.3 | (1.7, 16) |
| Menopausal status (≤6 months of diagnosis) | ||||||
| Pre-menopausal | 57 | 6.8 | (5.2, 8.9) | 51 | 6.1 | (4.6, 8.0) |
| Post-menopausal | 142 | 4.3 | (3.7, 5.1) | 180 | 5.5 | (4.7, 6.4) |
| 1st degree family history of breast cancer (before 1st diagnosis) | ||||||
| No | 195 | 5.2 | (4.5, 6.0) | 197 | 5.3 | (4.6, 6.1) |
| Yes | 46 | 4.9 | (3.6, 6.5) | 71 | 7.6 | (5.9, 9.5) |
| Breast density (before 1st diagnosis and within 2 years of mammogram used for mode of detection) | ||||||
| Almost entirely fatty | 11 | 7.0 | (3.5, 12.6) | 2 | 1.3 | (0.2, 4.6) |
| Scattered fibroglandular | 65 | 5.0 | (3.9, 6.4) | 64 | 5.0 | (3.8, 6.3) |
| Heterogeneously dense | 58 | 4.1 | (3.1, 5.4) | 108 | 7.7 | (6.3, 9.3) |
| Extremely dense | 21 | 6.8 | (4.2, 10.4) | 24 | 7.7 | (5.0, 11.5) |
| Self-reported lump before mammogram used for mode of detection | ||||||
| No | 165 | 4.5 | (3.8, 5.2) | 218 | 5.9 | (5.2, 6.8) |
| Yes | 66 | 7.1 | (5.5, 9.0) | 52 | 5.6 | (4.2, 7.3) |
BCS breast conserving surgery, ER estrogen receptor, PR progesterone receptor, CI confidence interval
a
Recurrent cancer includes a 2nd cancer in the same breast as the 1st cancer with the same histology for the 2nd breast cancer