Table 3.
Adjusted ORs (95% confidence interval) for selected SNPs by NHL subtype, Mayo Case-Control Study of NHL, 2002-2005.
| All NHL (n=441) |
CLL/SLL (n=123) |
Follicular Lymphoma (n=113) |
DLBCL (n=69) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP ID† | Major/Minor | Ordinal OR* | p-trend | Ordinal OR* | p-trend | Ordinal OR* | p-trend | Ordinal OR* | p-trend | p-heterogeneity^ |
| BAG5 | rs7693 | C/T | 1.24 (1.02, 1.50) | 0.031 | 1.25 (0.94, 1.67) | 0.13 | 1.31 (0.97, 1.77) | 0.084 | 1.67 (1.15, 2.43) | 0.0074 | 0.48 |
| BCL2L11 | rs6746608 | G/A | 0.82 (0.68, 1.00) | 0.049 | 0.74 (0.54, 1.00) | 0.049 | 0.87 (0.65, 1.18) | 0.38 | 0.91 (0.62, 1.34) | 0.63 | 0.57 |
| BCL2L11 | rs12613243 | T/C | 0.58 (0.38, 0.87) | 0.0087 | 0.41 (0.19, 0.88) | 0.022 | 0.57 (0.28, 1.12) | 0.10 | 1.24 (0.64, 2.39) | 0.52 | 0.047 |
| BCL2L11 | rs724710 | C/T | 0.89 (0.72, 1.09) | 0.26 | 0.78 (0.56, 1.09) | 0.14 | 0.94 (0.68, 1.29) | 0.69 | 1.07 (0.72, 1.59) | 0.73 | 0.39 |
| BCL2L11 | rs616130 | A/C | 0.87 (0.72, 1.05) | 0.15 | 0.79 (0.59, 1.07) | 0.13 | 0.88 (0.66, 1.29) | 0.42 | 0.98 (0.68, 1.43) | 0.93 | 0.65 |
| BCL2L11 | rs6753785 | C/A | 0.84 (0.69, 1.02) | 0.078 | 0.74 (0.55, 1.01) | 0.057 | 0.94 (0.70, 1.28) | 0.71 | 0.87 (0.60, 1.28) | 0.49 | 0.45 |
| BCLAF1 | rs797558 | C/G | 1.38 (1.07, 1.80) | 0.015 | 1.39 (0.94, 2.05) | 0.10 | 1.24 (0.82, 1.88) | 0.30 | 1.32 (0.81, 2.14) | 0.27 | 0.89 |
| BCLAF1 | rs703193 | C/T | 1.42 (1.10, 1.84) | 0.0073 | 1.43 (0.98, 2.10) | 0.066 | 1.32 (0.88, 1.97) | 0.17 | 1.40 (0.88, 2.25) | 0.16 | 0.94 |
| CASP9 | rs6685648 | T/C | 1.41 (1.14, 1.73) | 0.0013 | 1.60 (1.17, 2.19) | 0.0036 | 1.21 (0.86, 1.69) | 0.27 | 1.26 (0.84, 1.88) | 0.27 | 0.36 |
| CASP9 | rs4646077 | G/A | 0.87 (0.70, 1.08) | 0.20 | 1.07 (0.78, 1.46) | 0.68 | 0.79 (0.55, 1.12) | 0.18 | 0.55 (0.34, 0.89) | 0.016 | 0.049 |
| CASP9 | rs2308950 | G/A | 0.73 (0.35, 1.49) | 0.38 | 0.21 (0.03, 1.57) | 0.13 | 0.92 (0.31, 2.78) | 0.88 | 0.34 (0.04, 2.60) | 0.30 | 0.34 |
| CASP9 | rs2020902 | T/C | 0.74 (0.57, 0.95) | 0.019 | 0.85 (0.58, 1.24) | 0.40 | 0.72 (0.47, 1.10) | 0.12 | 0.43 (0.23, 0.80) | 0.0076 | 0.17 |
| CASP9 | rs4646018 | G/A | 0.84 (0.69, 1.02) | 0.078 | 0.65 (0.49, 0.88) | 0.0049 | 1.03 (0.76, 1.39) | 0.84 | 1.23 (0.85, 1.79) | 0.27 | 0.0098 |
| CASP9 | rs2042370 | T/C | 0.82 (0.68, 1.00) | 0.044 | 0.62 (0.46, 0.83) | 0.0015 | 1.07 (0.80, 1.44) | 0.65 | 1.14 (0.79, 1.64) | 0.48 | 0.0046 |
| CASP9 | rs2308941 | C/T | 0.72 (0.36, 1.45) | 0.36 | 0.83 (0.28, 2.49) | 0.74 | 1.49 (0.61, 3.63) | 0.38 | 0.30 (0.04, 2.31) | 0.25 | 0.27 |
*
ORs adjusted for age and sex
†
Reference sequence ID from dbSNP
^
p-value for test of heterogeneity between the CLL/SLL, Follicular Lymphoma, and DLBCL NHL subtypes as determined by polytomous logistic regression; CLL/SLL, chronic lymphocytic leukemia / small lymphocytic lymphoma; DLBCL, diffuse large B-cell lymphoma