Table I.

Symptoms and pathology in individual mice

	Symptoms			Pathology
Group (number of mice)*	Wasting	Leg paralysis	Other adverse symptoms **	Number of mice at necropsy †	Average day of necropsy	Secondary tumors	Enlarged spleen ‡	Granta cells in blood at necropsy
Control group (10 mice)	No mice	No mice	No mice	8	21.9	#33	All mice	All mice
Group 1 (11 mice)	#31,43,45	#29,45	#21,31,43	9	42.7	#29,44,45	#12,17,21,44,52	#12,17,21,44
Group 2 (9 mice)	#7,8,13,16,28	#7,16,28	#8	7	56	#8,25	#2,25,37,47	#2,37,47
Group 3 (7 mice)	#11,20,24,34,39,49	#39,49	#11,24,34,49	4	77.8	#11,24,34	No mice	#11,24,34

^*Experimental groups included initially about 12 mice but some sudden treatment-related fatalities occurred, especially after IV injection of virus or control Opti-MEM. The number of fatalities was highest in group 3, in which each animal received multiple rounds of treatment.

^**Other adverse symptoms included ascites, labored breathing, a hunched posture and body tremors.

^†Some mice were not available for necropsy.

^‡Enlarged spleen is defined as > 175% of the weight of age-matched normal SCID mice.